HRT Complete E

HRT Complete E is a precision-formulated, physician-grade nutraceutical designed to optimize estrogen metabolism, enhance hormonal balance, and support healthy aging in women. By targeting the critical methylation, detoxification, and conversion pathways of estrogen metabolism, this formula promotes the formation of protective estrogen metabolites while reducing the body's levels of harmful, pro-carcinogenic forms of estrogen. Featuring a synergistic blend of methylated B vitamins, bioavailable DIM®, antioxidant-rich CoQ10, Sulforaphane, and the clinically researched FenuSMART® Fenugreek, HRT Complete E is an essential daily component of any hormone replacement therapy (HRT) or menopause support protocol.

What It Is

A clinically formulated, two-capsule daily supplement designed to:

• Promote a healthy and safe estrogen metabolism pathway
• Support robust hormonal balance during perimenopause and menopause
• Enhance mood, libido, and overall metabolic health
• Reduce common menopausal symptoms such as night sweats, hot flashes, and weight gain
• Support the body's detoxification and clearance of excess estrogen

What It Does

• Regulates estrogen metabolism by promoting the safer 2-hydroxyestrone pathway
• Helps to reduce belly fat and manage hormone-related weight gain
• Enhances sexual function and libido through hormonal balance and targeted fenugreek support
• Improves mental clarity, energy, and mood through B vitamin and CoQ10 synergy
• Supports the detoxification of excess estrogens and environmental xenoestrogens
• May reduce estrogen-dominant symptoms including fibroids, breast tenderness, and mood swings
• Helps to prevent osteopenia and osteoporosis by improving hormone signaling

Who It's For

HRT Complete E is ideal for:

• Women who are undergoing hormone replacement therapy (HRT or EvexiPEL pellets)
• Perimenopausal and menopausal women who are experiencing hormone imbalances
• Individuals with symptoms of estrogen dominance such as fibroids, mood swings, weight gain, or hot flashes
• Women seeking comprehensive cardiovascular, cognitive, and metabolic support
• Adults looking to optimize their hormone detoxification and estrogen clearance pathways
• Patients with a family or personal history of estrogen-related cancers

Active Ingredients

Serving Size: 2 Capsules

• Vitamin B6 (Pyridoxal-5-Phosphate): 25 mg – Supports neurotransmitter function and estrogen clearance
• Folate (L-Methyltetrahydrofolate): 400 mcg (as DFE) – Essential for methylation and estrogen detoxification pathways
• Vitamin B12 (Methylcobalamin): 500 mcg – Promotes proper homocysteine metabolism and mood support
• EvexiPEL Proprietary Blend (750.75 mg):
• FenuSMART® Fenugreek Seed Extract: Clinically shown to support libido, hormonal balance, and sexual function
• DIM® (Diindolylmethane Complex): Shifts estrogen metabolism to protective pathways and supports detoxification
• Coenzyme Q10: Supports cardiovascular health, energy production, and hormone function
• Sulforaphane (from broccoli sprout extract): Enhances phase II detoxification, antioxidant defense, and cellular health

How it Works

HRT Complete E supports estrogen metabolism and detoxification through several critical mechanisms. DIM® and Sulforaphane work together to encourage phase I and phase II liver detoxification enzymes, effectively shifting estrogen breakdown toward the protective 2-hydroxyestrone pathway, which is associated with a lower risk of hormone-sensitive cancers. The methylated forms of B6, Folate, and B12 support the methylation-dependent clearance of estrogen and the regulation of homocysteine, which improves mood, cardiovascular health, and mental clarity. FenuSMART® Fenugreek naturally supports sexual function and libido in women by modulating estrogen and testosterone receptors, while CoQ10 provides mitochondrial and cardiovascular support, enhancing energy, endurance, and oxidative protection.

Key Health Benefits

• Effectively Balances Estrogen and Supports Healthy Hormone Metabolism
• Promotes a Healthy Libido, Balanced Mood, and Mental Clarity
• Supports Healthy Weight Management and the Reduction of Belly Fat
• Enhances Natural Detoxification and the Clearance of Excess Estrogen
• May Reduce the Risk for Hormone-Related Cancers
• Improves Sleep, Energy, and Resilience During Menopause
• Designed to Complement HRT and Pellet Therapy Protocols for Optimal Results

Conditions Supported

• Hormone Imbalance & Estrogen Dominance
• Menopause / Perimenopause Symptoms
• Hot Flashes, Mood Swings, Night Sweats
• Fibroids / Endometriosis
• Low Libido & Sexual Dysfunction
• Cardiovascular Disease
• Diabetes & Metabolic Syndrome
• Osteopenia & Osteoporosis
• Cognitive Issues / Brain Fog
• Detoxification & Weight Management

Why Choose EvexiPEL Nutraceuticals?

HRT Complete E was developed in direct alignment with EvexiPEL hormone pellet protocols to ensure safe and optimized support for hormone therapy patients. With clinical doses of targeted ingredients, it offers a holistic approach to hormone metabolism, detoxification, and symptom relief. For clinicians and patients seeking effective, evidence-based support for hormone optimization, HRT Complete E is the trusted daily supplement to restore balance, vitality, and longevity.